2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → HCID 69291047, compound

HRID 2224351Notes

Reaction equation

HRID 2224351 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]2[CH2:12][N:11]([C:13](=[O:15])[CH3:14])[C:10]3[CH:16]=[CH:17][CH:18]=[CH:19][C:9]=3[CH:8]=[CH:7][C:6]=2[CH:20]=1.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][C:26](B2OC(C)(C)C(C)(C)O2)=[CH:25][N:24]=1.C(N1C2C=CC=CC=2C=CC2N=C(C3C=NC(OC)=CC=3)C(F)=CC=2C1)(=O)C>>[C:13]([N:11]1[C:10]2[CH:16]=[CH:17][CH:18]=[CH:19][C:9]=2[CH:8]=[CH:7][C:6]2[CH:20]=[C:2]([C:26]3[CH:25]=[N:24][C:23]([O:22][CH3:21])=[CH:28][CH:27]=3)[CH:3]=[N:4][C:5]=2[CH2:12]1)(=[O:15])[CH3:14]

Participants

4

Reactant 3

HCID 162177142-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridineHCID 692892751-(3-bromo-12H-1,11-diaza-dibenzo[a,e]cycloocten-11-yl)-ethanoneHCID 692911976-Acetyl-3-fluoro-5,6-dihydro-2-(6-methoxy-3-pyridinyl)-pyrido[3,2-c][1]benzazocine

Product 1

HCID 69291047HCID 69291047, compoundYield 95.9%

Procedure

Compound 52D (20.9 mg, 91%) was prepared from 52C (20 mg, 0.061 mmol) and 2A (14.3 mg, 0.061 mmol) by a route analogous to that used for the preparation of 2B. HPLC Rt=2.419 min; LCMS Found: (M+H)+=358.

Sources & evidence

ORD record
ord-4c79482fb0c84cdeb2e3151701f7f6af
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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