3-Bromo-6-chloro-2-methylpyridine → 3-Bromo-2-(bromomethyl)-6-chloropyridine

HRID 2224353Notes

Reaction equation

HRID 2224353 reaction equation
[Br:1][C:2]1[C:3]([CH3:9])=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.[Br:10]C1C(CBr)=NC=C(Br)C=1>>[Br:1][C:2]1[C:3]([CH2:9][Br:10])=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 148666743-Bromo-6-chloro-2-methylpyridineHCID 534171773,5-Dibromo-2-(bromomethyl)pyridine

Product 1

HCID 232499153-Bromo-2-(bromomethyl)-6-chloropyridineYield 45%

Procedure

Compound 55B (0.33 g, 45%) was prepared from 55A (0.53 g, 2.57 mmol) using a procedure similar to the synthesis of 52B. HPLC Rt=2.47 min.

Sources & evidence

ORD record
ord-e81759140f404bed8febb149f307e60d
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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