2-(Dihydroxyboranyl)benzoic acid → 2-(11-Acetyl-11,12-dihydro-1,11-diaza-dibenzo[a,e]cycloocten-2-yl)-benzoic acid

HRID 2224357Notes

Reaction equation

HRID 2224357 reaction equation
Cl[C:2]1[CH:20]=[CH:19][C:5]2[CH:6]=[CH:7][C:8]3[CH:18]=[CH:17][CH:16]=[CH:15][C:9]=3[N:10]([C:12](=[O:14])[CH3:13])[CH2:11][C:4]=2[N:3]=1.[C:21]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1B(O)O)([OH:23])=[O:22].C(N1C2C=CC=CC=2C=CC2N=C(C3C=NC(OC)=CC=3)C(F)=CC=2C1)(=O)C>>[C:12]([N:10]1[C:9]2[CH:15]=[CH:16][CH:17]=[CH:18][C:8]=2[CH:7]=[CH:6][C:5]2[CH:19]=[CH:20][C:2]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=3[C:21]([OH:23])=[O:22])=[N:3][C:4]=2[CH2:11]1)(=[O:14])[CH3:13]

Participants

4

Reactant 3

HCID 27339852-(Dihydroxyboranyl)benzoic acidHCID 692911976-Acetyl-3-fluoro-5,6-dihydro-2-(6-methoxy-3-pyridinyl)-pyrido[3,2-c][1]benzazocineHCID 723667791-(2-chloro-12H-1,11-diaza-dibenzo[a,e]cycloocten-11-yl)-ethanone

Product 1

HCID 692915382-(11-Acetyl-11,12-dihydro-1,11-diaza-dibenzo[a,e]cycloocten-2-yl)-benzoic acid

Procedure

Compound 61A was prepared from 55C (17 mg, 0.060 mmol) and 2-carboxyphenylboronic acid (10 mg, 0.060 mmol) by a route analogous to that used for the preparation of 2B.

Sources & evidence

ORD record
ord-950306c94ce2466ca2bbcec98cd16ecd
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

Loading…