HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 69292180, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | Methylamine hydrochloride | HCID 6364545 | — |
| Reactant | 2-(11-Acetyl-11,12-dihydro-1,11-diaza-dibenzo[a,e]cycloocten-2-yl)-benzoic acid | HCID 69291538 | — |
| Product | HCID 69292180 | HCID 69292180 | 48% |
Reaction Steps
A mixture of 61A, MeNH2.HCl (20 mg, 0.30 mmol), BOP (37 mg, 0.084 mmol) and Et3N (50 μl, 0.036 mmol) was stirred at room temperature for 30 minutes. The reaction mixture was concentrated and purified by flash chromatography (SiO2, 100% CH2Cl2 then 100% EtOAc) to give 61B (11.1 mg, 48% for two steps). HPLC Rt=2.063 min; LCMS Found: (M+H)+=384.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07378426B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-0c3a1c62704041c6aeb1ab2ce18a92cb |
| Source note | uspto-grants-2008_05 |