2,4-Dichloro-5-(chloromethyl)pyrimidine → HCID 72366781, compound

HRID 2224359Notes

Reaction equation

HRID 2224359 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([CH2:9]Cl)=[CH:4][N:3]=1.[C:11]([N:14]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH:19]=[CH:18]C2N=C(Cl)C(F)=CC=2C1)(=[O:13])[CH3:12]>>[C:11]([N:14]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH:19]=[CH:18][C:6]2[N:7]=[C:2]([Cl:1])[N:3]=[CH:4][C:5]=2[CH2:9]1)(=[O:13])[CH3:12]

Participants

3

Reactant 2

HCID 135682792,4-Dichloro-5-(chloromethyl)pyrimidineHCID 743934126-Acetyl-2-chloro-3-fluoro-5,6-dihydro-pyrido[3,2-c][1]benzazocine

Product 1

HCID 72366781HCID 72366781, compoundYield 46%

Procedure

Compound 64B (66.1 mg, 46%) was prepared from 64A (0.10 g, 0.5 mmol) and bb (82 mg, 0.5 mmol) in two steps by a route analogous to that used for the preparation of 1D. HPLC Rt=2.286 min; LCMS Found: (M+H)+=286.

Sources & evidence

ORD record
ord-6e9609623108426998d50dc99277f512
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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