5-Bromo-3-(bromomethyl)-2-chloropyridine → N-(5-Bromo-2-chloro-pyridin-3-ylmethyl)-N-(4-chloro-2-vinyl-phenyl)-acetamide

HRID 2224362Notes

Reaction equation

HRID 2224362 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:9]Br)[C:5]([Cl:8])=[N:6][CH:7]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19](=[O:21])[CH3:20])=[C:14]([CH:22]=[CH2:23])[CH:13]=1.ClC1C(CN(C2C=CC=CC=2C=C)C(=O)C)=CC(F)=C(Cl)N=1>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:9][N:18]([C:15]2[CH:16]=[CH:17][C:12]([Cl:11])=[CH:13][C:14]=2[CH:22]=[CH2:23])[C:19](=[O:21])[CH3:20])[C:5]([Cl:8])=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 597175505-Bromo-3-(bromomethyl)-2-chloropyridineHCID 59717570N-(2,6-dichloro-5-fluoro-pyridin-3-ylmethyl)-N-(2-vinyl-phenyl)-acetamideHCID 59717611N-(4-chloro-2-vinyl-phenyl)-acetamide

Product 1

HCID 59717599N-(5-Bromo-2-chloro-pyridin-3-ylmethyl)-N-(4-chloro-2-vinyl-phenyl)-acetamideYield 94%

Procedure

Compound 76C (0.19 g, 94%) was prepared from 76B (0.145 g, 0.51 mmol) and 9B (0.1 mg, 0.51 mmol) using a procedure similar to the synthesis of 1C.

Sources & evidence

ORD record
ord-5f19775437bb4781824a2d24b51e0585
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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