4-Bromomethyl-2-chloro-5-iodo-pyridine → N-(2-Chloro-5-iodo-pyridin-4-ylmethyl)-N-(4-chloro-2-vinyl-phenyl)-acetamide

HRID 2224364Notes

Reaction equation

HRID 2224364 reaction equation
Br[CH2:2][C:3]1[C:8]([I:9])=[CH:7][N:6]=[C:5]([Cl:10])[CH:4]=1.BrC1C=C(C[N:20]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=2[CH:31]=[CH2:32])[C:21](=[O:23])[CH3:22])C(Cl)=NC=1.ClC1C(CN(C2C=CC=CC=2C=C)C(=O)C)=CC(F)=C(Cl)N=1>>[Cl:10][C:5]1[CH:4]=[C:3]([CH2:2][N:20]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=2[CH:31]=[CH2:32])[C:21](=[O:23])[CH3:22])[C:8]([I:9])=[CH:7][N:6]=1

Participants

4

Reactant 3

HCID 597175634-Bromomethyl-2-chloro-5-iodo-pyridineHCID 59717570N-(2,6-dichloro-5-fluoro-pyridin-3-ylmethyl)-N-(2-vinyl-phenyl)-acetamideHCID 59717599N-(5-Bromo-2-chloro-pyridin-3-ylmethyl)-N-(4-chloro-2-vinyl-phenyl)-acetamide

Product 1

HCID 59717576N-(2-Chloro-5-iodo-pyridin-4-ylmethyl)-N-(4-chloro-2-vinyl-phenyl)-acetamide

Procedure

Compound 77B was prepared from 77A (0.75 mg, 0.22 mmol) and 76C (0.44 g, 0.22 mmol) using a procedure similar to the synthesis of 1C.

Sources & evidence

ORD record
ord-bd5c6546150240fd97a069bc90d5837e
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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