反应详情

A solution of phenylsulfonyl chloride (10 mL, 78 mmol) in THF (50 mL) was cooled to 0° C. and treated dropwise with dimethylamine (20 mL) as a 40% solution in water maintaining a temperature below 50° C. The reaction was warmed to room temperature for one hour and poured into water. The solution was concentrated to remove THF and the residue was cooled to 0° C. The resulting solid was filtered and dried in vacuo to afford 83A (14 g, 97%).

1. concentrationThe solution was concentrated
2. customto remove THF
3. temperaturethe residue was cooled to 0° C
4. filtrationThe resulting solid was filtered
5. customdried in vacuo