Hydrochloric Acid → HCID 11713921, compound

HRID 2224465Notes

Reaction equation

HRID 2224465 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:14]2[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[N:17]3[N:24]=[CH:25][C:26]([C:27]([OH:29])=O)=[C:16]3[N:15]=2)[CH:7]=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])[CH3:2].[CH3:30][S:31]([C:34]1[CH:35]=[C:36]([NH2:40])[CH:37]=[CH:38][CH:39]=1)(=[O:33])=[O:32].Cl>>[CH3:30][S:31]([C:34]1[CH:35]=[C:36]([NH:40][C:27]([C:26]2[CH:25]=[N:24][N:17]3[C:18]([C:20]([F:22])([F:23])[F:21])=[CH:19][C:14]([C:6]4[CH:7]=[CH:8][C:9]([C:10]([F:11])([F:13])[F:12])=[C:4]([O:3][CH2:1][CH3:2])[CH:5]=4)=[N:15][C:16]=23)=[O:29])[CH:37]=[CH:38][CH:39]=1)(=[O:32])=[O:33]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 4280293-(Methylsulphonyl)anilineHCID 866071135-(3-Ethoxy-4-trifluoromethyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 11713921HCID 11713921, compound

Procedure

The title compound was prepared from 5-(3-ethoxy-4-trifluoromethyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.11) and 3-methanesulfonyl-phenylamine [commercially available as hydrochloride] according to general procedure II. Yellow solid. MS (ISP) 573.2 [(M+H)+]; mp 215° C.

Sources & evidence

ORD record
ord-9f6af5baa88347c9bd772ace8cff3eff
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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