Hydrochloric Acid → HCID 11706682, compound

HRID 2224466Notes

Reaction equation

HRID 2224466 reaction equation
[F:1][CH:2]([F:28])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=O)=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[C:17]([O:25][CH2:26][CH3:27])[CH:16]=2)[CH:4]=1.[CH3:29][S:30]([C:33]1[CH:34]=[C:35]([NH2:39])[CH:36]=[CH:37][CH:38]=1)(=[O:32])=[O:31].Cl>>[CH3:29][S:30]([C:33]1[CH:34]=[C:35]([NH:39][C:12]([C:11]2[CH:10]=[N:9][N:8]3[C:3]([CH:2]([F:1])[F:28])=[CH:4][C:5]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:22])[F:23])=[C:17]([O:25][CH2:26][CH3:27])[CH:16]=4)=[N:6][C:7]=23)=[O:14])[CH:36]=[CH:37][CH:38]=1)(=[O:31])=[O:32]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 4280293-(Methylsulphonyl)anilineHCID 66650197HCID 66650197, compound

Product 1

HCID 11706682HCID 11706682, compound

Procedure

The title compound was prepared from 7-difluoromethyl-5-(3-ethoxy-4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.12) and 3-methanesulfonyl-phenylamine [commercially available as hydrochloride] according to general procedure II. Yellow solid. MS (ISP) 555.3 [(M+H)+]; mp 211° C.

Sources & evidence

ORD record
ord-c047a640f3624d058ee32f6e6a1a5cc2
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

Loading…