Hydrochloric Acid → HCID 11520043, compound

HRID 2224478Notes

Reaction equation

HRID 2224478 reaction equation
[F:1][CH:2]([F:31])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12](O)=[O:13])=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[C:17]([O:25][CH2:26][C:27]([F:30])([F:29])[F:28])[CH:16]=2)[CH:4]=1.[CH3:32][S:33]([C:36]1[CH:37]=[C:38]([NH2:42])[CH:39]=[CH:40][CH:41]=1)(=[O:35])=[O:34].Cl>>[CH3:32][S:33]([C:36]1[CH:37]=[C:38]([NH:42][C:12]([C:11]2[CH:10]=[N:9][N:8]3[C:3]([CH:2]([F:31])[F:1])=[CH:4][C:5]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:23])[F:24])=[C:17]([O:25][CH2:26][C:27]([F:30])([F:28])[F:29])[CH:16]=4)=[N:6][C:7]=23)=[O:13])[CH:39]=[CH:40][CH:41]=1)(=[O:34])=[O:35]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 4280293-(Methylsulphonyl)anilineHCID 86611628HCID 86611628, compound

Product 1

HCID 11520043HCID 11520043, compound

Procedure

The title compound was prepared from 7-difluoromethyl-5-[3-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.13) and 3-methanesulfonyl-phenylamine [commercially available as hydrochloride] according to general procedure II. Yellow solid. MS (EI) 608.3 [M]; mp 207° C.

Sources & evidence

ORD record
ord-41d24f6aba0e483aa4bc84080e6e0a2c
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

Loading…