Hydrochloric Acid → HCID 11554958, compound

HRID 2224482Notes

Reaction equation

HRID 2224482 reaction equation
[F:1][CH:2]([F:23])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=O)=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([CH3:22])[CH:16]=2)[CH:4]=1.[CH3:24][S:25]([C:28]1[CH:29]=[C:30]([NH2:34])[CH:31]=[CH:32][CH:33]=1)(=[O:27])=[O:26].Cl>>[CH3:24][S:25]([C:28]1[CH:29]=[C:30]([NH:34][C:12]([C:11]2[CH:10]=[N:9][N:8]3[C:3]([CH:2]([F:1])[F:23])=[CH:4][C:5]([C:15]4[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([CH3:22])[CH:16]=4)=[N:6][C:7]=23)=[O:14])[CH:31]=[CH:32][CH:33]=1)(=[O:26])=[O:27]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 4280293-(Methylsulphonyl)anilineHCID 66650512HCID 66650512, compound

Product 1

HCID 11554958HCID 11554958, compound

Procedure

The title compound was prepared from 7-difluoromethyl-5-(3-methyl-4-chloro-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (Example C.14) and 3-methanesulfonyl-phenylamine [commercially available as hydrochloride] according to general procedure II. Yellow solid. MS (ISP) 488.9 [(M−H)−]; mp 270° C.

Sources & evidence

ORD record
ord-92800c13259d431ea26cb62ce294f941
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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