Ethanol, 2-[(3-aminophenyl)sulfonyl]- → HCID 11512019, compound

HRID 2224489Notes

Reaction equation

HRID 2224489 reaction equation
[F:1][CH:2]([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=O)=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.OCCS(C1C=C(C=CC=1)[NH2:35])(=O)=O.[N+:39]([C:42]1[CH:43]=[C:44]([CH2:48][S:49](Cl)(=[O:51])=[O:50])[CH:45]=[CH:46][CH:47]=1)([O-])=O>>[S:49]([CH2:48][C:44]1[CH:43]=[C:42]([NH:39][C:12]([C:11]2[CH:10]=[N:9][N:8]3[C:3]([CH:2]([F:1])[F:25])=[CH:4][C:5]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:23])[F:24])=[CH:17][CH:16]=4)=[N:6][C:7]=23)=[O:14])[CH:47]=[CH:46][CH:45]=1)(=[O:51])(=[O:50])[NH2:35]

Participants

4

Reactant 3

HCID 78905Ethanol, 2-[(3-aminophenyl)sulfonyl]-HCID 13196775(3-Nitrophenyl)methanesulfonyl chlorideHCID 666502687-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 11512019HCID 11512019, compound

Procedure

The title compound was prepared from 7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.1) and 3-(2-hydroxy-ethanesulfonyl)-aniline [CAS-Nr. 344750-15-8; prepared from commercially available 3-nitro-phenylmethane-sulfonyl chloride] according to general procedure II. Yellow solid. MS (ISP) 524.0 [(M−H)−]; mp 280° C.

Sources & evidence

ORD record
ord-771d53e6c4924c6ca2a3b64556aecf3c
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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