Ethanol, 2-[(3-aminophenyl)sulfonyl]- → HCID 11541170, compound

HRID 2224490Notes

Reaction equation

HRID 2224490 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12](O)=[O:13])=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.OCCS(C1C=C(C=CC=1)[NH2:36])(=O)=O.[N+:40]([C:43]1[CH:44]=[C:45]([CH2:49][S:50](Cl)(=[O:52])=[O:51])[CH:46]=[CH:47][CH:48]=1)([O-])=O>>[S:50]([CH2:49][C:45]1[CH:44]=[C:43]([NH:40][C:12]([C:11]2[CH:10]=[N:9][N:8]3[C:3]([C:2]([F:26])([F:25])[F:1])=[CH:4][C:5]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=4)=[N:6][C:7]=23)=[O:13])[CH:48]=[CH:47][CH:46]=1)(=[O:52])(=[O:51])[NH2:36]

Participants

4

Reactant 3

HCID 78905Ethanol, 2-[(3-aminophenyl)sulfonyl]-HCID 13196775(3-Nitrophenyl)methanesulfonyl chlorideHCID 866071127-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 11541170HCID 11541170, compound

Procedure

The title compound was prepared from 7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.2) and 3-(2-hydroxy-ethanesulfonyl)-aniline [CAS-Nr. 344750-15-8; prepared from commercially available 3-nitro-phenylmethane-sulfonyl chloride] according to general procedure II. Yellow solid. MS (ISP) 542.0 [(M−H)−]; mp 298° C.

Sources & evidence

ORD record
ord-eeb87425cf414d79bdcca672c6744528
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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