Hydrochloric Acid → HCID 11562763, compound

HRID 2224499Notes

Reaction equation

HRID 2224499 reaction equation
[F:1][CH:2]([F:26])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12](O)=[O:13])=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[C:17]([F:25])[CH:16]=2)[CH:4]=1.[CH3:27][S:28]([C:31]1[CH:32]=[C:33]([NH2:37])[CH:34]=[CH:35][CH:36]=1)(=[O:30])=[O:29].Cl>>[CH3:27][S:28]([C:31]1[CH:32]=[C:33]([NH:37][C:12]([C:11]2[CH:10]=[N:9][N:8]3[C:3]([CH:2]([F:26])[F:1])=[CH:4][C:5]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:24])[F:23])=[C:17]([F:25])[CH:16]=4)=[N:6][C:7]=23)=[O:13])[CH:34]=[CH:35][CH:36]=1)(=[O:29])=[O:30]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 4280293-(Methylsulphonyl)anilineHCID 86611630HCID 86611630, compound

Product 1

HCID 11562763HCID 11562763, compound

Procedure

The title compound was prepared from 7-difluoromethyl-5-(3-fluoro-4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.16) and 3-methanesulfonyl-phenylamine [commercially available as hydrochloride] according to general procedure II. Light brown solid. MS (ISP) 527.0 [(M+H)+]; mp 238° C.

Sources & evidence

ORD record
ord-e8691970abc14c168c6eb5213d240b6d
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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