Hydrochloric Acid → HCID 11713643, compound

HRID 2224512Notes

Reaction equation

HRID 2224512 reaction equation
[F:1][C:2]([F:27])([F:26])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[N:13]3[N:20]=[CH:21][C:22]([C:23](O)=[O:24])=[C:12]3[N:11]=2)=[CH:6][CH:5]=1.[CH3:28][S:29]([C:32]1[CH:33]=[C:34]([NH2:38])[CH:35]=[CH:36][CH:37]=1)(=[O:31])=[O:30].Cl>>[CH3:28][S:29]([C:32]1[CH:33]=[C:34]([NH:38][C:23]([C:22]2[CH:21]=[N:20][N:13]3[C:14]([C:16]([F:18])([F:19])[F:17])=[CH:15][C:10]([C:7]4[CH:6]=[CH:5][C:4]([O:3][C:2]([F:27])([F:26])[F:1])=[CH:9][CH:8]=4)=[N:11][C:12]=23)=[O:24])[CH:35]=[CH:36][CH:37]=1)(=[O:30])=[O:31]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 4280293-(Methylsulphonyl)anilineHCID 87090280HCID 87090280, compound

Product 1

HCID 11713643HCID 11713643, compound

Procedure

The title compound was prepared from 5-(4-trifluoromethoxy-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.19) and 3-methanesulfonyl-phenylamine [commercially available as hydrochloride] according to general procedure II. Yellow solid. MS (ISP) 545.3 [(M+H)+]; mp 245° C.

Sources & evidence

ORD record
ord-cdbefdcf01ee4b5bb66dee5e7148d576
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

Loading…