Sodium Methoxide → HCID 11561583, compound

HRID 2224568Notes

Reaction equation

HRID 2224568 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([NH:11][C:12]([C:14]2[CH:15]=[N:16][N:17]3[C:22](Cl)=[CH:21][C:20]([C:24]4[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=4)=[N:19][C:18]=23)=[O:13])[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3].[CH3:31][O-:32].[Na+]>CO>[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([NH:11][C:12]([C:14]2[CH:15]=[N:16][N:17]3[C:22]([O:32][CH3:31])=[CH:21][C:20]([C:24]4[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=4)=[N:19][C:18]=23)=[O:13])[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 11641183HCID 11641183, compound

Product 1

HCID 11561583HCID 11561583, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared by stirring 7-chloro-5-(4-chloro-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid(3-methanesulfonyl-phenyl)-amide (example 175) (46 mg) with a solution of sodium methoxide (11 mg) in methanol (1.5 mL) for 2 h at 50° C., followed by precipitation of the product by the addition of water (10 mL). Pale-yellow solid. MS (ISP) 457.5 [(M+H)+]; mp 265° C.

Workup

  1. customfollowed by precipitation of the product by the addition of water (10 mL)

Sources & evidence

ORD record
ord-beabb401cff3453b9d7b6537651c6cbe
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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