反应详情

温度

35 °C

To a stirred suspension of 2-(2′-phthalimidoethyl) benzaldehyde (900 gm, 3.22 mol), in methanol (9.0 Lt) were added nitromethane (521 ml, 9.65 mol), acetic acid (349 ml, 6.1 mol), n-butyl amine (486 ml, 4.72 mol) and trimethyl orthoformate (499 ml, 3 mol) at room temperature. The reaction mixture was then stirred at 30-40° C. for 30 hrs. The greenish coloured solid was filtered at suction, washed with chilled methanol (700 ml) and dried at 50° C. for 8 hrs. This gave the title compound, 649 gm, (62.5%) in the form of cream coloured solid

1. filtrationThe greenish coloured solid was filtered at suction
2. washwashed with chilled methanol (700 ml)
3. customdried at 50° C. for 8 hrs