Phosphorus oxybromide → 3-Bromo-6-phenylpyridazine

Participants

Reaction Conditions

Reaction Steps

Dissolve 6-Phenylpyridazin-3-ol (5.0 g, 29.06 mmol) in toluene (100 mL) and heat to 90° C. Add phosphorous oxybromide (25 g, 87.19 mmol) in several portions and heat the reaction for 30 minutes. Cool the resulting yellow solution to room temperature, pour onto ice water, and extract with ethyl acetate. Further wash the organic layers with water and 1 M NaOH, dry over MgSO4, filter, and evaporate to a yellow solid. Recrystallization from CHCl3 gives 2.17 g of 3-bromo-6-phenylpyridazine.

Provenance & Evidence