Diethyl Malonate → Dimethyl 2-(2-isopentyl-5-methyl-2-phenylhexanoyl)malonate

HRID 2224782Notes

Reaction equation

HRID 2224782 reaction equation
[C:1]([O:9][CH2:10]C)(=[O:8])[CH2:2][C:3]([O:5][CH2:6]C)=[O:4].[CH2:12]([C:17]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)([CH2:21][CH2:22][CH:23]([CH3:25])[CH3:24])[C:18](Cl)=[O:19])[CH2:13][CH:14]([CH3:16])[CH3:15].C1(C(CCC)(CCC)C(Cl)=O)C=CC=CC=1>>[CH2:12]([C:17]([C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)([CH2:21][CH2:22][CH:23]([CH3:24])[CH3:25])[C:18]([CH:2]([C:1]([O:9][CH3:10])=[O:8])[C:3]([O:5][CH3:6])=[O:4])=[O:19])[CH2:13][CH:14]([CH3:16])[CH3:15]

Participants

4

Reactant 3

HCID 7761Diethyl MalonateHCID 116873352-Phenyl-2-propylpentanoyl chlorideHCID 865980202-isopentyl-5-methyl-2-phenylhexanoyl Chloride

Product 1

HCID 69270654Dimethyl 2-(2-isopentyl-5-methyl-2-phenylhexanoyl)malonate

Procedure

The title compound was prepared following the procedure of Example 1E, substituting dimethyl malonate for diethyl malonate, and substituting the product of Example 6D for the product of Example 1D. 1H NMR (300 MHz, CDCl3): δ 7.32 (m, 5 H), 4.54 (s, 1 H), 3.56 (s, 6 H), 2.00 (m, 4 H), 1.49 (m, 2 H), 0.87 (m, 16 H).

Sources & evidence

ORD record
ord-c3229670b61a4c24a9139e34b0595623
Source dataset
uspto-grants-2008_05
Patent number
US07378414B2

Reaction notes

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