HCID 68870329, compound → HCID 68871351, compound

HRID 2224821Notes

Reaction equation

HRID 2224821 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@:8]([CH3:26])([CH2:21][CH2:22][CH:23]([CH3:25])[CH3:24])[C:9](N[C@H](C2C=CC=CC=2)CO)=[O:10])=[CH:4][CH:3]=1.FC1C=CC([C@@](C)(CCC(C)C)C(N[C@H](C2C=CC=CC=2)CO)=[O:36])=CC=1>CCO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C@:8]([CH3:26])([CH2:21][CH2:22][CH:23]([CH3:25])[CH3:24])[C:9]([OH:10])=[O:36])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 68870329HCID 68870329, compoundHCID 68871587HCID 68871587, compound

Product 1

HCID 68871351HCID 68871351, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared according to the procedure of Example 22E, substituting the product of Example 23A, for the product of Example 22D. 1H NMR (300 MHz, CDCl3): δ 0.88 (m, 7 H) 1.06 (m, 1 H) 1.48 (m, 1 H) 1.55 (s, 3 H) 1.96 (m, 2 H) 3.76 (m, 2 H) 5.03 (m, 1 H) 5.83 (d, J=6.99 Hz, 1 H) 7.06 (m, 4 H) 7.29 (m, 5 H). Specific rotation: [α]D +12.4° (c 2.16, EtOH).

Sources & evidence

ORD record
ord-cd93b28d57b04b2c9246f31d163cfa9d
Source dataset
uspto-grants-2008_05
Patent number
US07378414B2

Reaction notes

Loading…