HCID 69268285, compound → HCID 68871219, compound

HRID 2224867Notes

Reaction equation

HRID 2224867 reaction equation
[CH:1]1(/[CH:7]=[CH:8]/[CH2:9][C:10]([CH3:27])([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:11]([O:13]CC2C=CC=CC=2)=[O:12])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C(OCC)(=O)C.[Pd]>[CH:1]1([CH2:7][CH2:8][CH2:9][C:10]([CH3:27])([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:11]([OH:13])=[O:12])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 1

HCID 69268285HCID 69268285, compound

Product 1

HCID 68871219HCID 68871219, compoundYield 104.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of Example 36C (3.52 g, 9.71 mmol) in ethyl acetate (50 mL) was treated with 10% palladium on carbon (0.352 g, 10 weight percent) and stirred under a hydrogen balloon for 72 hours. The vessel was purged with nitrogen gas and the mixture was filtered through a pad of celite and the filtrate was concentrated in vacuo to give the title compound (2.79 g, 99%).

Workup

  1. customThe vessel was purged with nitrogen gas
  2. filtrationthe mixture was filtered through a pad of celite
  3. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-8c05be85419a44f181cb428061fa89f1
Source dataset
uspto-grants-2008_05
Patent number
US07378414B2

Reaction notes

Loading…