Sodium Hydroxide → HCID 68873989, compound

HRID 2224870Notes

Reaction equation

HRID 2224870 reaction equation
[CH:1]1([CH2:7][CH2:8][CH2:9][C:10]2([CH3:34])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]([OH:20])=[C:12]([C:21]3[NH:26][C:25]4[CH:27]=[CH:28][CH:29]=[CH:30][C:24]=4[S:23](=[O:32])(=[O:31])[N:22]=3)[C:11]2=[O:33])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+:36]>O>[CH:1]1([CH2:7][CH2:8][CH2:9][C:10]2([CH3:34])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]([O-:20])=[C:12]([C:21]3[NH:26][C:25]4[CH:27]=[CH:28][CH:29]=[CH:30][C:24]=4[S:23](=[O:32])(=[O:31])[N:22]=3)[C:11]2=[O:33])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Na+:36]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 135436731HCID 135436731, compound

Product 1

HCID 68873989HCID 68873989, compoundYield 986.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

A suspension of the product of Example 36I (0.77 g) in water (2 mL) was treated with 0.997N sodium hydroxide solution (0.161 mL, 0.160 mmol) and stirred at 25° C. for 1 hour. The solution was lyophilized to give the title compound (0.79 g, 99%). 1H NMR (300 MHz, DMSO-d6): δ ppm 0.84 m, 11 H) 1.45 m, 7 H) 1.68 m, 1 H) 2.10 m, 1 H) 7.31 m, 3 H) 7.49 m, 3 H) 7.65 m, 1 H) 8.05 m, 1 H) 15.45 m, 1 H). MS (ESI−) m/z 477 (M−H)−.

Sources & evidence

ORD record
ord-5045dba91fd045b0954516b4fa9b3fda
Source dataset
uspto-grants-2008_05
Patent number
US07378414B2

Reaction notes

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