Hydrochloric Acid → HCID 136403544, compound

HRID 2224874Notes

Reaction equation

HRID 2224874 reaction equation
[CH:1]1([CH2:7][CH2:8][CH2:9][C:10]2([CH3:42])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]([OH:20])=[C:12]([C:21]3[NH:26][C:25]4[CH:27]=[CH:28][C:29]([NH:31]C(=O)OC(C)(C)C)=[CH:30][C:24]=4[S:23](=[O:40])(=[O:39])[N:22]=3)[C:11]2=[O:41])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:43]>O1CCOCC1>[ClH:43].[NH2:31][C:29]1[CH:28]=[CH:27][C:25]2[NH:26][C:21]([C:12]3[C:11](=[O:41])[C:10]([CH2:9][CH2:8][CH2:7][CH:1]4[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]4)([CH3:42])[C:19]4[C:14]([C:13]=3[OH:20])=[CH:15][CH:16]=[CH:17][CH:18]=4)=[N:22][S:23](=[O:40])(=[O:39])[C:24]=2[CH:30]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136384885HCID 136384885, compound

Product 1

HCID 136403544HCID 136403544, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of Example 38A (0.570 g, 0.960 mmol) in 4M hydrochloric acid in 1,4-dioxane (10 mL) was stirred at 25° C. for 1 hour. The solution was concentrated in vacuo and the residue was triturated in diethyl ether to give the title compound (0.357 g, 70%).

Workup

  1. concentrationThe solution was concentrated in vacuo
  2. customthe residue was triturated in diethyl ether

Sources & evidence

ORD record
ord-1dc5a77cb3c04ec480d299619d802e03
Source dataset
uspto-grants-2008_05
Patent number
US07378414B2

Reaction notes

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