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温度

0 °C

Preparation B1, Step 2: The allyl 2-amino-5-(trifluoromethyl)benzoate from step 1 (ca. 15.7 mmol) was dissolved in THF (60 mL) and phosgene (24.9 mL, 47 mmol) was added at 0° C. dropwise. The reaction was stirred for 15 minutes at 0° C. Triethylamine (13.1 mL, 94 mmol) was slowly added and stirring was continued for 2 hours. The reaction was concentrated in vacuo to afford a yellow solid. A portion (2.4 g, ca. 7.7 mmol) of the yellow solid was dissolved in THF (40 mL) and the solution was charged with ethylamine (20 mL of a 2.0 M solution in THF). The reaction was stirred for 14 h at RT and then diluted with EtOAc. The organic phase was washed successively with 1N HCl (2×) and brine (1×) before being dried (Na2SO4), filtered, and concentrated in vacuo to give allyl 2-(3-ethylureido)-5-(trifluoromethyl)benzoate as a white solid (1.8 g). MS found: (M+Na)+=339.29.

1. stirringstirring
2. waitwas continued for 2 hours
3. concentrationThe reaction was concentrated in vacuo
4. customto afford a yellow solid
5. stirringThe reaction was stirred for 14 h at RT
6. washThe organic phase was washed successively with 1N HCl (2×) and brine (1×)
7. dry with materialbefore being dried (Na2SO4)
8. filtrationfiltered
9. concentrationconcentrated in vacuo