反应详情

Preparation D10, Step 2: 2-butyramido-5-chlorobenzamide (1.08 g, 4.49 mmol, 1 eq) was dissolved in ethanol (10 mL) at room temperature then 1N NaOH (13.46 mL, 13.5 mmol, 3 eq) added. Worked up after 15 minutes by adding 1N HCl to pH=2. Solids precipitated and were filtered and pumped under high vacuum to give 6-chloro-2-propylquinazolin-4-ol (810 mg) as a white solid. Yield=81%. Mass Spec (ESI) (M+H)+=223.0.

1. customPreparation D10, Step 2
2. customSolids precipitated
3. filtrationwere filtered