反应详情

16 Grams of lithium aluminum hydride was suspended in 200 ml of dried tetrahydrofuran, then 16 g of 3-methoxycarbonylcarbostyril was added thereto at a room temperature with stirring. The reaction mixture was further stirred for 5 hours at a room temperature. The excess lithium aluminum hydride in the reaction mixture was decomposed by adding ethyl acetated dropwise. Further, water was added to the reaction mixture and concentrated under a reduced pressure to obtain residue. To the residue was added a diluted sulfuric acid and the precipitated crystals were collected by filtration and recrystallized from methanol to obtain 3.7 g of 3-hydroxymethylcarbostyril in the form of colorless prism-like crystals.

1. stirringThe reaction mixture was further stirred for 5 hours at a room temperature
2. additionby adding ethyl
3. concentrationconcentrated under a reduced pressure
4. customto obtain residue
5. filtrationthe precipitated crystals were collected by filtration
6. customrecrystallized from methanol