Hydrogen Bromide → HCID 67820012, compound

HRID 2225343Notes

Reaction equation

HRID 2225343 reaction equation
Cl.[NH2:2][CH:3]([CH2:7][C:8]1[C:9](=[O:20])[NH:10][C:11]2[C:16]([CH:17]=1)=[CH:15][C:14]([O:18]C)=[CH:13][CH:12]=2)[C:4]([OH:6])=[O:5].[BrH:21]>>[BrH:21].[NH2:2][CH:3]([CH2:7][C:8]1[C:9](=[O:20])[NH:10][C:11]2[C:16]([CH:17]=1)=[CH:15][C:14]([OH:18])=[CH:13][CH:12]=2)[C:4]([OH:6])=[O:5]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 13342125HCID 13342125, compound

Product 1

HCID 67820012HCID 67820012, compound

Procedure

To 6 g of 2-amino-3-(6-methoxy-2-quinolon-3-yl)propionic acid hydrochloride was added 60 ml of 47%-hydrobromic acid, and the mixture was refluxed for 7 hours. After the reaction mixture was cooled, the crystals precipitated were collected by filtration, then recrystallized from water to obtain 1.8 g of 2-amino-3-(6-hydroxy-2-quinolon-3-yl)proprionic acid hydrobromide in the form of yellowish powdery product.

Workup

  1. temperaturethe mixture was refluxed for 7 hours
  2. temperatureAfter the reaction mixture was cooled
  3. customthe crystals precipitated
  4. filtrationwere collected by filtration
  5. customrecrystallized from water

Sources & evidence

ORD record
ord-38cae802dc824580b502d223528a4119
Source dataset
uspto-grants-1994_09
Patent number
USRE034722

Reaction notes

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