HCID 11514549, compound → HCID 13342162, compound

HRID 2225344Notes

Reaction equation

HRID 2225344 reaction equation
[ClH:1].[NH2:2][CH:3]([CH2:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][C:10](=[O:18])[CH:9]=1)[C:4]([OH:6])=[O:5].[H][H]>O.[C].[Pd]>[ClH:1].[NH2:2][CH:3]([CH2:7][CH:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][C:10](=[O:18])[CH2:9]1)[C:4]([OH:6])=[O:5]

Participants

5

Reactant 2

HCID 11514549HCID 11514549, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13342162HCID 13342162, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 962WaterSolvent

Procedure

5 Grams of 2-amino-3-(2-quinolon-4-yl)propionic acid hydrochloride was dissolved in 150 ml of water. To this solution was added 1 g of 10%-palladium carbon, then hydrogen gas was adsorbed thereto at 70° C. under a normal pressure. The catalyst was removed from the reaction mixture by filtration, then the filtrate was concentrated under a reduced pressure. The residue thus obtained was crystallized by adding acetone, then recrystallized from ethanol-ether to obtain 3.6 g of 2-amino-3-(3,4-dihydroquinolin-2-on-4-yl)propionic acid hydrochloride in the form of white powdery product.

Workup

  1. customat 70° C.
  2. customThe catalyst was removed from the reaction mixture by filtration
  3. concentrationthe filtrate was concentrated under a reduced pressure
  4. customThe residue thus obtained
  5. customwas crystallized
  6. additionby adding acetone
  7. customrecrystallized from ethanol-ether

Sources & evidence

ORD record
ord-4919c0d85faf4f8a994144b73e45bbd2
Source dataset
uspto-grants-1994_09
Patent number
USRE034722

Reaction notes

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