HCID 11514549, compound → HCID 13342162, compound

Participants

Reaction Steps

5 Grams of 2-amino-3-(2-quinolon-4-yl)propionic acid hydrochloride was dissolved in 150 ml of water. To this solution was added 1 g of 10%-palladium carbon, then hydrogen gas was adsorbed thereto at 70° C. under a normal pressure. The catalyst was removed from the reaction mixture by filtration, then the filtrate was concentrated under a reduced pressure. The residue thus obtained was crystallized by adding acetone, then recrystallized from ethanol-ether to obtain 3.6 g of 2-amino-3-(3,4-dihydroquinolin-2-on-4-yl)propionic acid hydrochloride in the form of white powdery product.

Provenance & Evidence