Hydrochloric Acid → HCID 16218315, compound

HRID 2225347Notes

Reaction equation

HRID 2225347 reaction equation
C([NH:4][CH:5]([CH2:9][C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[NH:13][C:12](=[O:20])[CH:11]=1)[C:6]([OH:8])=[O:7])(=[O:3])C.[ClH:21]>>[OH2:3].[ClH:21].[NH2:4][CH:5]([CH2:9][C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[NH:13][C:12](=[O:20])[CH:11]=1)[C:6]([OH:8])=[O:7]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 10016156HCID 10016156, compound

Product 1

HCID 16218315HCID 16218315, compound

Procedure

To 2.7 g of 2-acetylamino-3-(2-quinolon-4-yl)propionic acid was added 30 ml of 20%-hydrochloric acid and the mixture was refluxed for 3 hours. The reaction mixture was concentrated under a reduced pressure to dryness, the residue obtained was recrystallized from ethanol-water to obtain 1.9 g of 2-amino-3-(2-quinolon-4-yl)propionic acid hydrochloride hydrate in the form of colorless prism-like crystals.

Workup

  1. temperaturethe mixture was refluxed for 3 hours
  2. concentrationThe reaction mixture was concentrated under a reduced pressure to dryness
  3. customthe residue obtained
  4. customwas recrystallized from ethanol-water

Sources & evidence

ORD record
ord-a8fb9a09794f4acfbc37413b82019dd9
Source dataset
uspto-grants-1994_09
Patent number
USRE034722

Reaction notes

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