HCID 67820159, compound → HCID 67820103, compound

HRID 2225348Notes

Reaction equation

HRID 2225348 reaction equation
[ClH:1].[NH2:2][C:3](=[CH:7][C:8]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]2[C:9]=1[CH:10]=[CH:11][C:12](=[O:20])[NH:13]2)[C:4]([OH:6])=[O:5]>[OH-].[Na+].[Ni]>[OH2:5].[ClH:1].[NH2:2][CH:3]([CH2:7][C:8]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]2[C:9]=1[CH:10]=[CH:11][C:12](=[O:20])[NH:13]2)[C:4]([OH:6])=[O:5]

Participants

4

Reactant 1

HCID 67820159HCID 67820159, compound

Product 1

HCID 67820103HCID 67820103, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 14798Sodium HydroxideSolvent

Procedure

6 Grams of 2-amino-3-(8-methoxy-2-quinolon-5-yl)acrylic acid hydrochloride was dissolved in 100 ml of 1N-sodium hydroxide aqueous solution. To this solution was added 2 g of Raney nickel and hydrogenation was carried out at a room temperature under 3 atmospheric pressure. The catalyst was removed by filtration, the mother liquor was neutralized with acetic acid, and allowed to stand in a refrigerator, the crystals precipitated were collected by filtration. Recrystallized from water to obtain 2 g of 2-amino-3-(8-methoxy-2-quinolon-5-yl)propionic acid hydrochloride hydrate in the form of colorless powdery product.

Workup

  1. customwas carried out at a room temperature under 3 atmospheric pressure
  2. customThe catalyst was removed by filtration
  3. customthe crystals precipitated
  4. filtrationwere collected by filtration
  5. customRecrystallized from water

Sources & evidence

ORD record
ord-1c3b53352494416e82690394f70c0044
Source dataset
uspto-grants-1994_09
Patent number
USRE034722

Reaction notes

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