HCID 67820159, compound → HCID 67820103, compound

Participants

Reaction Steps

6 Grams of 2-amino-3-(8-methoxy-2-quinolon-5-yl)acrylic acid hydrochloride was dissolved in 100 ml of 1N-sodium hydroxide aqueous solution. To this solution was added 2 g of Raney nickel and hydrogenation was carried out at a room temperature under 3 atmospheric pressure. The catalyst was removed by filtration, the mother liquor was neutralized with acetic acid, and allowed to stand in a refrigerator, the crystals precipitated were collected by filtration. Recrystallized from water to obtain 2 g of 2-amino-3-(8-methoxy-2-quinolon-5-yl)propionic acid hydrochloride hydrate in the form of colorless powdery product.

Provenance & Evidence