反应详情

A mixture of 3.14 g of 2-chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine and 1.20 g of ethyl acrylate in 16 ml of ethanol was refluxed for 2 hrs. The reaction mixture was concentrated and the residue was chromatographed on silica gel using a mixture of n-hexane and ethyl acetate (2:1 and 1:1) as eluents to give 3.68 g of yellow crystals, which were recrystallized from a mixture of isopropyl ether and n-pentane to give yellow prisms, mp 73°-75° C.

1. temperaturewas refluxed for 2 hrs
2. concentrationThe reaction mixture was concentrated
3. customthe residue was chromatographed on silica gel using
4. additiona mixture of n-hexane and ethyl acetate (2:1 and 1:1) as eluents