Ethyl Acrylate → HCID 19004092, compound

HRID 2225373Notes

Reaction equation

HRID 2225373 reaction equation
[CH2:1]1[CH:6]2[C:7]3[CH:19]=[CH:18][CH:17]=[CH:16][C:8]=3[CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[N:5]2[CH2:4][CH2:3][NH:2]1.[C:20]([O:24][CH2:25][CH3:26])(=[O:23])[CH:21]=[CH2:22]>C(O)C>[CH2:1]1[CH:6]2[C:7]3[CH:19]=[CH:18][CH:17]=[CH:16][C:8]=3[CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[N:5]2[CH2:4][CH2:3][N:2]1[CH2:22][CH2:21][C:20]([O:24][CH2:25][CH3:26])=[O:23]

Participants

4

Reactant 2

HCID 8821Ethyl AcrylateHCID 115194Desmethylmianserin

Product 1

HCID 19004092HCID 19004092, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2.50 g of 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine and 1.20 g of ethyl acrylate in 13 ml of ethanol was refluxed for 3 hrs. The reaction mixture was concentrated and the residue was chromatographed on silica gel using a mixture of n-hexane and ethyl acetate (1:1) as an eluent to give 3.08 g of colorless crystals, which were recrystallized from isopropyl ether to give colorless needles, mp 159°-160° C.

Workup

  1. temperaturewas refluxed for 3 hrs
  2. concentrationThe reaction mixture was concentrated
  3. customthe residue was chromatographed on silica gel using
  4. additiona mixture of n-hexane and ethyl acetate (1:1) as an eluent

Sources & evidence

ORD record
ord-86327e780ee74a1289560ffddd0f1f43
Source dataset
uspto-grants-1994_09
Patent number
US05344828

Reaction notes

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