反应详情

20 ml of a 2N aqueous sodium hydroxide solution was added to a solution of 2.1 g of methyl 4-acetyl-1-methyl-1-cyclohexanecarboxylate (Example 35) in 20 ml of ethanol. The solution was reacted for 4 hours, while it was refluxed. After reaction, 2N hydrochloric acid was added to the reaction solution, acidifying the solution. The solution was extracted three times with 50 ml of ethyl acetate. The organic layer obtained was washed twice with an aqueous sodium chloride solution and dried over magnesium sulfate. The solvent was removed in vacuo, and the product obtained was recrystallized from ethyl acetate/hexane, yielding 1.4 g of 4-acetyl-1-methyl-1-cyclohexanecarboxylic acid as white crystal, which had the following physiochemical properties:

1. customThe solution was reacted for 4 hours, while it
2. temperaturewas refluxed
3. additionwas added to the reaction solution
4. extractionThe solution was extracted three times with 50 ml of ethyl acetate
5. customThe organic layer obtained
6. washwas washed twice with an aqueous sodium chloride solution
7. dry with materialdried over magnesium sulfate
8. customThe solvent was removed in vacuo
9. customthe product obtained
10. customwas recrystallized from ethyl acetate/hexane