4-Methylcyclohexylamine Hydrochloride → N-(4-methylcyclohexyl)-4-acetoxy-3-methoxycinnamamide

HRID 2225511Notes

Reaction equation

HRID 2225511 reaction equation
[C:1]([O:4][C:5]1[CH:15]=[CH:14][C:8]([CH:9]=[CH:10][C:11](Cl)=[O:12])=[CH:7][C:6]=1[O:16][CH3:17])(=[O:3])[CH3:2].Cl.[CH3:19][CH:20]1[CH2:25][CH2:24][CH:23]([NH2:26])[CH2:22][CH2:21]1>N1C=CC=CC=1>[CH3:19][CH:20]1[CH2:25][CH2:24][CH:23]([NH:26][C:11](=[O:12])[CH:10]=[CH:9][C:8]2[CH:14]=[CH:15][C:5]([O:4][C:1](=[O:3])[CH3:2])=[C:6]([O:16][CH3:17])[CH:7]=2)[CH2:22][CH2:21]1

Participants

4

Reactant 2

HCID 127141254-Methylcyclohexylamine HydrochlorideHCID 544680224-Acetoxy-3-methoxycinnamoyl chloride

Product 1

HCID 54149475N-(4-methylcyclohexyl)-4-acetoxy-3-methoxycinnamamideYield 65.3%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Using 5.09 g of 4-acetoxy-3-methoxycinnamoyl chloride, 2.98 g of 4-methylcyclohexylamine hydrochloride, and 100 ml of pyridine, a reaction similar to that conducted in Example 53 was carried out. As a result, 4.31 g of N-(4-methylcyclohexyl)-4-acetoxy-3-methoxycinnamamide was obtained as yellowish white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-e63df6ef2bfa45a3a342f1ac852c67e6
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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