Sodium → HCID 59780474, compound

HRID 222554Notes

Reaction equation

HRID 222554 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]([CH2:19][CH2:20][OH:21])=[CH:6]2)[CH3:2].[Na]>CCO>[CH2:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[NH:9][C@@H:8]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C@H:7]([CH2:19][CH2:20][OH:21])[CH2:6]2)[CH3:2]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 59780476HCID 59780476, compound

Product 1

HCID 59780474HCID 59780474, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described under b.), 0.80 g (2.88 mmol) of 7 were reacted with 0.66 g (28.8 mmol, 10 eq) of sodium in EtOH (10 ml) to give compound trans-8 as a colourless solid and compound cis-8, likewise as a colourless solid.

Workup

  1. customto give compound trans-8 as a colourless solid and compound cis-8

Sources & evidence

ORD record
ord-c095c2cc65644a8e8c247824e46c3e23
Source dataset
uspto-grants-2012_06
Patent number
US08207345B2

Reaction notes

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