Ethanol → HCID 59780469, compound

HRID 222556Notes

Reaction equation

HRID 222556 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]([CH2:18][C:19]([OH:21])=[O:20])=[CH:5]2.[CH3:22][CH2:23]O>S(=O)(=O)(O)O>[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:5]2

Participants

4

Reactant 2

HCID 702EthanolHCID 59780451HCID 59780451, compound

Product 1

HCID 59780469HCID 59780469, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidCatalyst

Procedure

0.50 g (1.80 mmol) of 13 was dissolved in 10 ml of EtOH, one drop of conc. sulfuric acid was added, and the mixture was heated under reflux for 2 h. The solvent was removed, the residue was taken up in ethyl acetate and washed 2× with water. The organic phase was dried and evaporated. The colourless oily residue is compound 16.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 2 h
  3. customThe solvent was removed
  4. washwashed 2× with water
  5. customThe organic phase was dried
  6. customevaporated

Sources & evidence

ORD record
ord-5c15f0b74a8a42a281a610c457063134
Source dataset
uspto-grants-2012_06
Patent number
US08207345B2

Reaction notes

Loading…