Pyrrolidine → HCID 178490534, compound

HRID 2225569Notes

Reaction equation

HRID 2225569 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:24])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20]Cl)=[C:14]([O:22][CH3:23])[CH:13]=2)[CH2:4][CH2:3]1.[NH:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1>>[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:24])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][N:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)=[C:14]([O:22][CH3:23])[CH:13]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 178490530HCID 178490530, compound

Product 1

HCID 178490534HCID 178490534, compound

Procedure

Using 3.9 g of N-(trans-4-methylcyclohexyl)-4-(2-chloroethoxy)-3-methoxycinnamamide (Example 138) and 18 ml of pyrrolidine, a reaction similar to that conducted in Example 142 was carried out. As a result, 2.68 g of N-(trans-4-methylcyclohexyl)-4-[2-(1-pyrrolidinyl)ethoxy]-3-methoxycinnamamide (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-b5c983a5e6f246bb92ae8d390a17fb67
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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