1,4'-Bipiperidine → HCID 178490539, compound

HRID 2225585Notes

Reaction equation

HRID 2225585 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[CH:6]=[CH:7][C:8]([NH2:10])=[O:9].[N:14]1([CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>CC(CC(C)C)=O>[CH3:6][C@H:5]1[CH2:11][CH2:12][C@H:13]([NH:10][C:8](=[O:9])[CH:7]=[CH:6][C:5]2[CH:11]=[CH:12][C:13]([O:9][CH2:8][CH2:7][N:23]3[CH2:24][CH2:25][CH:20]([N:14]4[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]4)[CH2:21][CH2:22]3)=[C:3]([O:2][CH3:1])[CH:4]=2)[CH2:3][CH2:4]1

Participants

4

Reactant 2

HCID 786071,4'-BipiperidineHCID 572965063-(3-Methoxyphenyl)prop-2-enamide

Product 1

HCID 178490539HCID 178490539, compound

Reagents, catalysts & solvents 1

HCID 7909Methyl Isobutyl KetoneSolvent

Procedure

Using 1.9 g N-(trans-4-methylcyclohexyl)-4-chloroethoxy)-3-methoxycinnamamide (Example 138), 4.56 g of 4-piperidinopiperidine, and 50 ml of methylisobutylketone, a reaction similar to that conducted in Example 142 was carried out. As a result, 1.51 g of N-(trans-4-methylcyclohexyl)-4-[2-(4-piperidinopiperidino)ethoxy]-3-methoxycinnamamide (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-c577ee254a294632aaeab912c4601104
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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