HCID 178462640, compound → HCID 178462641, compound

HRID 2225588Notes

Reaction equation

HRID 2225588 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:30])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][C:21]3[N:22]([CH2:26][CH3:27])[CH:23]=[CH:24][N:25]=3)=[C:14]([O:28][CH3:29])[CH:13]=2)[CH2:4][CH2:3]1>[C].[Pd].CO>[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:30])[CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][C:21]3[N:22]([CH2:26][CH3:27])[CH:23]=[CH:24][N:25]=3)=[C:14]([O:28][CH3:29])[CH:13]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 1

HCID 178462640HCID 178462640, compound

Product 1

HCID 178462641HCID 178462641, compoundYield 69.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Using 0.2 g of N-(trans-4-methylcyclohexyl)-4-{2-[1-(2-ethyl)imidazoly]ethoxy}-3-methoxycinnamamide (Example 162), 0.01 g of 10% palladium-carbon, and 25 ml of methanol, a reaction similar to that conducted in Example 147 was performed. As a result, 0.14 g of N-(trans-4-methylcyclohexyl)-3-{4-{2-[1-(2-ethyl)imidazolyl]ethoxy}-3-methoxyphenyl}propionamide (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-aa3bc92f69f64f518bbc3595fae6109e
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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