Potassium Hydroxide → HCID 178490527, compound

HRID 2225594Notes

Reaction equation

HRID 2225594 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:29])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][C:22]([O:24]CC)=[O:23])=[C:14]([O:27][CH3:28])[CH:13]=2)[CH2:4][CH2:3]1.[OH-].[K+]>CO>[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:29])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][C:22]([OH:24])=[O:23])=[C:14]([O:27][CH3:28])[CH:13]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 178471691HCID 178471691, compound

Product 1

HCID 178490527HCID 178490527, compoundYield 91.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using 1.6 g of N-(trans-4-methylcyclohexyl)-4-[3(ethoxycarbonyl)propoxy]-3-methoxycinnamamide (Example 174), 20 ml of 2 M aqueous potassium hydroxide solution, and 80 ml of methanol, a reaction similar to that conducted in Example 169 was carried out. As a result, 1.36 g of N-(trans-4-methylcyclohexyl)-4-(3-carboxypropoxy) -3-methoxycinnamamide (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-2b8b49ed0e5f45cdac07377d55896ff2
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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