HCID 178490527, compound → HCID 178490528, compound

HRID 2225595Notes

Reaction equation

HRID 2225595 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:27])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][C:22]([OH:24])=[O:23])=[C:14]([O:25][CH3:26])[CH:13]=2)[CH2:4][CH2:3]1>[C].[Pd].CO>[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:27])[CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][C:22]([OH:24])=[O:23])=[C:14]([O:25][CH3:26])[CH:13]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 1

HCID 178490527HCID 178490527, compound

Product 1

HCID 178490528HCID 178490528, compoundYield 64.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Using 0.2 g of N-(trans-4-methylcyclohexyl)-4-(3-carboxypropoxy) -3-methoxycinnamamide (Example 175), 0.01 g of 10% palladium-carbon, and 35 ml of methanol, a reaction similar to that conducted in Example 147 was carried out. As a result, 0.13 g of N-(trans-4-methylcyclohexyl) -3-[4-(3-carboxypropoxy)-3-methoxyphenyl]propionamide (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-dc5fd6df73c143a884b4341e2f55f570
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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