HCID 178490517, compound → HCID 178490518, compound

HRID 2225600Notes

Reaction equation

HRID 2225600 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:28])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][C:21]3[CH:25]=[CH:24][NH:23][N:22]=3)=[C:14]([O:26][CH3:27])[CH:13]=2)[CH2:4][CH2:3]1>[C].[Pd].CO>[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:28])[CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][C:21]3[CH:25]=[CH:24][NH:23][N:22]=3)=[C:14]([O:26][CH3:27])[CH:13]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 1

HCID 178490517HCID 178490517, compound

Product 1

HCID 178490518HCID 178490518, compoundYield 49.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Using 0.1 g of N-(trans-4-methylcyclohexyl )-4-(2-pyrazolylethoxy) -3-methoxycinnamamide (Example 180), 0.007 g of 10% palladium-carbon, and 30 ml of methanol, a reaction similar to that conducted in Example 147 was carried out. As a result, 0.05 g of N-(trans-4-methylcyclohexyl) -3-[4-(2-pyrazolylethoxy)-3methoxyphenyl]propionamide (a compound of the present invention) was obtained as light-yellowish brown crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-43d22f83409e4a3e9cb02379b9386992
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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