HCID 178490554, compound → HCID 178490555, compound

HRID 2225605Notes

Reaction equation

HRID 2225605 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9]([CH:11]=[CH:12][C:13]2[CH:34]=[CH:33][C:16]([O:17][CH2:18][C:19]([N:21]3[CH2:26][CH2:25][CH:24]([N:27]4[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]4)[CH2:23][CH2:22]3)=[O:20])=[C:15]([O:35][CH3:36])[CH:14]=2)=[O:10])[CH2:4][CH2:3]1>[C].[Pd].CO>[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9]([CH2:11][CH2:12][C:13]2[CH:34]=[CH:33][C:16]([O:17][CH2:18][C:19]([N:21]3[CH2:22][CH2:23][CH:24]([N:27]4[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]4)[CH2:25][CH2:26]3)=[O:20])=[C:15]([O:35][CH3:36])[CH:14]=2)=[O:10])[CH2:4][CH2:3]1

Participants

4

Reactant 1

HCID 178490554HCID 178490554, compound

Product 1

HCID 178490555HCID 178490555, compoundYield 59.8%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Using 0.2 g of 1-{4-{2-[N-(trans-4methylcyclohexyl)carbamoyl]vinyl}-2-methoxyphenoxyacetyl}-4-piperidinopiperidine (Example 190), 0.01 g of 10% palladium-carbon, and 30 ml of methanol, a reaction similar to that conducted in Example 147 was carried out. As a result, 0.12 g of 1-{4-{2- [N-(trans-4-methylcyclohexyl) carbamoyl]ethyl}- 2-methoxyphenoxyacetyl}-4-piperidinopiperidine (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-d9d2f2e5c6c14ef0aabcfdde0419df71
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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