反应详情

A solution of 2-methoxythiophene (2.28 g) and 2-(2-naphthalenyloxy)ethanol (4.0 g) in benzene (35 mL) containing para-toluenesulfonic acid (0.02 g) was stirred at reflux for 3 days in a flask equipped with a Soxhlet extractor charged with 4 Å molecular sieves. The mixture was cooled, washed with 0.5N sodium hydroxide solution, dried over anhydrous magnesium sulfate (MgSO4) and evaporated. Crystallization of the residual material from ethanol (30 mL) provided 2.68 g of 2-[[2-(2-naphthalenyloxy)ethyl]oxy]thiophene as colorless flakes, mp 129°-130 ° C.

1. temperatureat reflux for 3 days in a flask
2. customequipped with a Soxhlet extractor
3. additioncharged with 4 Å molecular sieves
4. temperatureThe mixture was cooled
5. washwashed with 0.5N sodium hydroxide solution
6. dry with materialdried over anhydrous magnesium sulfate (MgSO4)
7. customevaporated
8. customCrystallization of the residual material from ethanol (30 mL)