Methyl phenylglyoxalate → HCID 19004392, compound

HRID 2225630Notes

Reaction equation

HRID 2225630 reaction equation
C[O:2][C:3](=[O:12])[C:4](=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[C:5]1([CH2:4][CH2:3][O:2][C:8]2[CH:9]=[CH:10][C:5]([C:4](=[O:11])[C:3]([OH:2])=[O:12])=[CH:6][CH:7]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 1

HCID 84835Methyl phenylglyoxalate

Product 1

HCID 19004392HCID 19004392, compoundYield 112.4%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 4-[(2-phenylethyl)oxy)]-alpha-oxobenzeneacetic acid methyl ester (0.4 g) in methanol and 0.5N sodium hydroxide (8 mL) was treated as in Example 19 and the crude product was crystallized from benzene-hexane to give 0.37 g of 4-[(2-phenylethyl)oxy]-alpha-oxobenzeneacetic acid as a colorless solid, mp 72°-73° C.

Workup

  1. additionwas treated as in Example 19
  2. customthe crude product was crystallized from benzene-hexane

Sources & evidence

ORD record
ord-4d1e675db3c14f3d9b9b0ef75732be82
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

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