HCID 54243338, compound → HCID 19004462, compound

HRID 2225632Notes

Reaction equation

HRID 2225632 reaction equation
C[O:2][C:3](=[O:22])[C:4](=[O:21])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[C:15]1([CH2:14][CH2:13][CH2:12][O:11][C:8]2[CH:7]=[CH:6][C:5]([C:4](=[O:21])[C:3]([OH:22])=[O:2])=[CH:10][CH:9]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 1

HCID 54243338HCID 54243338, compound

Product 1

HCID 19004462HCID 19004462, compoundYield 72.6%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 4-[(3-phenylpropyl)oxy]-alpha-oxobenzeneacetic acid methyl ester (0.65 g) in methanol and 0.5N sodium hydroxide (8 mL) was treated as in Example 19. Extraction provided 0.6 g which solidified and was crystallized from benzene-hexane to give 0.45 g of colorless 4-[(3-phenylpropyl)oxy]-alpha-oxobenzeneacetic acid, mp 58°-59° C.

Workup

  1. additionwas treated as in Example 19
  2. extractionExtraction
  3. customprovided 0.6 g which
  4. customwas crystallized from benzene-hexane

Sources & evidence

ORD record
ord-33c70746287b4c36ab0c6e7210f6f8e6
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

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