HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[[3-(4-Fluorophenyl)propyl]oxy]-alpha-oxobenzeneacetic acid methyl ester → 4-[[3-(4-Fluorophenyl)propyl]oxy]-alpha-oxobenzeneacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[[3-(4-Fluorophenyl)propyl]oxy]-alpha-oxobenzeneacetic acid methyl ester | HCID 54198850 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 4-[[3-(4-Fluorophenyl)propyl]oxy]-alpha-oxobenzeneacetic acid | HCID 19004472 | 77.6% |
Reaction Steps
A mixture of 4-[[3-(4-fluorophenyl)propyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.58 g) in methanol and 0.5N sodium hydroxide (8 mL) was treated as in Example 19. Extraction provided 0.55 g which solidified and was crystallized from diethyl etherhexane to give 0.43 g of colorless 4-[[3-(4-fluorophenyl)propyl]oxy]-alpha-oxobenzeneacetic acid, mp 77°-78° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05344843 |
| Source dataset | uspto-grants-1994_09 |
| ORD ID | ord-204eb29e15b14e779b6304c9e3a0686d |
| Source note | uspto-grants-1994_09 |